While the comics were a cult hit, the franchise reached its peak of global fame with the . This side-scrolling "beat 'em up" followed the formula perfected by Final Fight , but with a prehistoric twist.

: In one of the game's most memorable sequences, players could actually drive Jack's Cadillac through a stage, mowing down enemies in a high-speed chase.

: Players chose from four heroes: the mechanic Jack Tenrec , the diplomat Hannah Dundee , the powerhouse Mustapha Cairo , and the gentle giant Mess O'Bradovich .

The story is set in the , centuries after a series of environmental cataclysms forced humanity to live in underground bunkers. When they finally emerged, they found the Earth's ecosystem completely transformed: prehistoric beasts—dinosaurs, pterosaurs, and giant mammals—had returned to reclaim the planet.

To capitalize on the game's success, a Cadillacs and Dinosaurs animated series was produced by in 1993. It aired for one season (13 episodes) and stayed relatively true to Schultz's vision, focusing on the environmental themes of the comics.