Check your Quarantine folder to see if settings.exe was moved there. Move the Folder Out of System Directories
Does it show up in Task Manager for a second then disappear? Are you using any mods like Sider or SmokePatch?
If you tell me more about what happens when you click the file, I can narrow this down: Any specific error codes (like 0xc000007b)? pes 2021 settingsexe not opening new
Check the box for Run this program in compatibility mode for and select Windows 8. Click Apply and try opening the file again. Update DirectX and .NET Framework
💡 : If the file still won't open, you can manually edit your settings by finding the settings.dat file in your Documents\KONAMI\eFootball PES 2021 Season Update folder, though using the .exe is much safer for most users. Check your Quarantine folder to see if settings
Install the Visual C++ Redistributable Packages (both x86 and x64 versions) for 2015, 2017, and 2019. Verify Integrity of Game Files
If the settings.exe file itself is corrupted, Steam can detect and replace it. Open your Steam Library. Right-click on eFootball PES 2021. Select Properties and then the Local Files tab. Click Verify integrity of game files. If you tell me more about what happens
Sometimes, security software flags the settings tool as a "false positive" and kills the process before it can open. Temporarily disable your real-time antivirus protection.